Proteins/UNIPROT:P24158

PRTN3

ProteinUNIPROT:P24158

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. Plays a role in neutrophil transendothelial migration, probably when associated with CD177. Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation..

Function from UniProtKB (P24158), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

26 statements

26 statements · 3 reference databases · Subject: PRTN3 · Sources: gene ontology, Hetionet, Reactome

Order

ELN interacts with PRTN3ProteinHetionet hetionet:interacts:2006-5657Inferred only
F2R interacts with PRTN3ProteinHetionet hetionet:interacts:2149-5657Inferred only
F2RL1 interacts with PRTN3ProteinHetionet hetionet:interacts:2150-5657Inferred only
IL1B interacts with PRTN3ProteinHetionet hetionet:interacts:3553-5657Inferred only
PRTN3 interacts with IL32ProteinHetionet hetionet:interacts:5657-9235Inferred only
ITGAM interacts with PRTN3ProteinHetionet hetionet:interacts:3684-5657Inferred only
ITGB2 interacts with PRTN3ProteinHetionet hetionet:interacts:3689-5657Inferred only
PRTN3 interacts with RELAProteinHetionet hetionet:interacts:5657-5970Inferred only
SERPINA1 interacts with PRTN3ProteinHetionet hetionet:interacts:5265-5657Inferred only
SERPINB1 interacts with PRTN3ProteinHetionet hetionet:interacts:1992-5657Inferred only
SERPINB13 interacts with PRTN3ProteinHetionet hetionet:interacts:5275-5657Inferred only
SMAD3 interacts with PRTN3ProteinHetionet hetionet:interacts:4088-5657Inferred only

Show the remaining 14

PRTN3 interacts with TNFProteinHetionet hetionet:interacts:5657-7124Inferred only
PRTN3 participates in Antimicrobial peptidesPathwayReactome R-HSA-6803157Inferred only
PRTN3 participates in Coagulation pathwayPathwayReactome R-HSA-9769740Inferred only
PRTN3 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
PRTN3 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
PRTN3 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
PRTN3 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
PRTN3 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
PRTN3 participates in Other interleukin signalingPathwayReactome R-HSA-449836Inferred only
PRTN3 participates in Regulation of clotting cascadePathwayReactome R-HSA-9769739Inferred only
PRTN3 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
PRTN3 regulates negative regulation of phagocytosisBiological processgene ontology P24158|GO:0050765Inferred only
PRTN3 regulates positive regulation of cell population proliferationBiological processgene ontology P24158|GO:0008284Inferred only
PRTN3 regulates positive regulation of GTPase activityBiological processgene ontology P24158|GO:0043547Inferred only

Other names

10 names

Resolves to: PRTN3

Also called: AGP7C-ANCA antigenLeukocyte proteinase 3MBNNeutrophil proteinase 4NP-4P29PR-3PR3Wegener autoantigen

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