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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P23942

PRPH2

Protein·UNIPROT:P23942

Open in the graph

Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure (By similarity). Required for the maintenance of retinal outer nuclear layer thickness (By similarity). Required for the correct development and organization of the photoreceptor inner segment (By similarity)..

Function from UniProtKB (P23942), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

15 rows · Showing 12

adult-onset foveomacular vitelliform dystrophy has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0011979Inferred only
central areolar choroidal dystrophy has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0008982Inferred only
choroidal dystrophy, central areolar 2 has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0013137Inferred only
cone-rod dystrophy has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0015993Inferred only
fundus albipunctatus has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0007639Inferred only
hereditary macular dystrophy has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0020242Inferred only
inherited retinal dystrophy has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0019118Inferred only
Leber congenital amaurosis has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0018998Inferred only
multifocal pattern dystrophy simulating fundus flavimaculatus has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0020382Inferred only
patterned macular dystrophy has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0020381Inferred only
PRPH2-related retinopathy has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:1040055Inferred only
retinitis pigmentosa has a germline basis in PRPH2DiseaseGenCC HGNC:9942|MONDO:0019200Inferred only

Statements

13 statements

13 statements · 1 reference database · Subject: PRPH2 · Sources: Hetionet

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PRPH2 covaries with AKT1ProteinHetionet hetionet:covaries:207-5961Inferred only
AP1S2 covaries with PRPH2ProteinHetionet hetionet:covaries:5961-8905Inferred only
GAS1 covaries with PRPH2ProteinHetionet hetionet:covaries:2619-5961Inferred only
PRPH2 covaries with H2BC4; H2BC6; H2BC7; H2BC8; H2BC10ProteinHetionet hetionet:covaries:5961-8339Inferred only
PRPH2 covaries with POLR2HProteinHetionet hetionet:covaries:5437-5961Inferred only
PRPH2 covaries with SLC17A7ProteinHetionet hetionet:covaries:57030-5961Inferred only
PRPH2 covaries with SPRED3ProteinHetionet hetionet:covaries:399473-5961Inferred only
PRPH2 covaries with TIGD2ProteinHetionet hetionet:covaries:166815-5961Inferred only
VCP covaries with PRPH2ProteinHetionet hetionet:covaries:5961-7415Inferred only
CNGB1 interacts with PRPH2ProteinHetionet hetionet:interacts:1258-5961Inferred only
PRPH2 interacts with GRAP2ProteinHetionet hetionet:interacts:5961-9402Inferred only
PRPH interacts with PRPH2ProteinHetionet hetionet:interacts:5630-5961Inferred only

Show the remaining 1

PRPH2 interacts with ROM1ProteinHetionet hetionet:interacts:5961-6094Inferred only

Other names

6 names

Resolves to: PRPH2

Also called: PRPHRDSRetinal degeneration slow proteinTetraspanin-22Tspan-22TSPAN22

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