Proteins/UNIPROT:Q9NQX1

PRDM5

ProteinUNIPROT:Q9NQX1

Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells..

Function from UniProtKB (Q9NQX1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

brittle cornea syndrome has a germline basis in PRDM5DiseaseGenCC HGNC:9349|MONDO:0009242Inferred only
brittle cornea syndrome 2 has a germline basis in PRDM5DiseaseGenCC HGNC:9349|MONDO:0013605Inferred only

Statements

14 statements

14 statements · 2 reference databases · Subject: PRDM5 · Sources: gene ontology, Hetionet

Order

NKX2-5 covaries with PRDM5ProteinHetionet hetionet:covaries:11107-1482Inferred only
EHMT2 interacts with PRDM5ProteinHetionet hetionet:interacts:10919-11107Inferred only
GFI1 interacts with PRDM5ProteinHetionet hetionet:interacts:11107-2672Inferred only
HDAC1 interacts with PRDM5ProteinHetionet hetionet:interacts:11107-3065Inferred only
PRDM5 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q9NQX1|GO:0045892Inferred only
PRDM5 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NQX1|GO:0000122Inferred only
PRDM5 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9NQX1|GO:0045944Inferred only
PRDM5 regulates regulation of extracellular matrix organizationBiological processgene ontology Q9NQX1|GO:1903053Inferred only
PRDM5 increases the expression of CSRP1ProteinHetionet hetionet:regulates:11107-1465Inferred only
PRDM5 decreases the expression of KLHL9ProteinHetionet hetionet:regulates:11107-55958Inferred only
PRDM5 decreases the expression of RNF167ProteinHetionet hetionet:regulates:11107-26001Inferred only
PRDM5 increases the expression of SERPINA3ProteinHetionet hetionet:regulates:11107-12Inferred only

Show the remaining 2

PRDM5 decreases the expression of SMC1AProteinHetionet hetionet:regulates:11107-8243Inferred only
PRDM5 increases the expression of STX1AProteinHetionet hetionet:regulates:11107-6804Inferred only

Other names

2 names

Resolves to: PRDM5

Also called: PFM2PR domain-containing protein 5

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