Proteins/UNIPROT:Q6IN85

PPP4R3A

ProteinUNIPROT:Q6IN85

Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair..

Function from UniProtKB (Q6IN85), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 3 reference databases · Subject: PPP4R3A · Sources: gene ontology, Hetionet, WikiPathways

Order

CEACAM20 covaries with PPP4R3AProteinHetionet hetionet:covaries:125931-55671Inferred only
EMC3 covaries with PPP4R3AProteinHetionet hetionet:covaries:55671-55831Inferred only
IFNA7 covaries with PPP4R3AProteinHetionet hetionet:covaries:3444-55671Inferred only
POLR2F covaries with PPP4R3AProteinHetionet hetionet:covaries:5435-55671Inferred only
SRSF2 covaries with PPP4R3AProteinHetionet hetionet:covaries:55671-6427Inferred only
UBE2QL1 covaries with PPP4R3AProteinHetionet hetionet:covaries:134111-55671Inferred only
MAPK14 interacts with PPP4R3AProteinHetionet hetionet:interacts:1432-55671Inferred only
PPP4C interacts with PPP4R3AProteinHetionet hetionet:interacts:5531-55671Inferred only
PPP4R3A interacts with PPP4R2ProteinHetionet hetionet:interacts:151987-55671Inferred only
UBC interacts with PPP4R3AProteinHetionet hetionet:interacts:55671-7316Inferred only
PPP4R3A participates in 16p11 2 proximal deletion syndromePathwayWikiPathways WP4949Inferred only
PPP4R3A participates in Integrated breast cancer pathwayPathwayWikiPathways WP1984Inferred only

Show the remaining 6

PPP4R3A regulates regulation of double-strand break repairBiological processgene ontology Q6IN85|GO:2000779Inferred only
ATG7 increases the expression of PPP4R3AProteinHetionet hetionet:regulates:10533-55671Inferred only
KHDC4 decreases the expression of PPP4R3AProteinHetionet hetionet:regulates:22889-55671Inferred only
PSMD10 increases the expression of PPP4R3AProteinHetionet hetionet:regulates:5716-55671Inferred only
PTMS increases the expression of PPP4R3AProteinHetionet hetionet:regulates:5763-55671Inferred only
STAT3 increases the expression of PPP4R3AProteinHetionet hetionet:regulates:6774-55671Inferred only

Other names

5 names

Resolves to: PPP4R3A

Also called: KIAA2010PP4R3ASerine/threonine-protein phosphatase 4 regulatory subunit 3ASMEK homolog 1SMEK1

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