Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q00005

PPP2R2B

Protein·UNIPROT:Q00005

Open in the graph

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity)..

Function from UniProtKB (Q00005), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

neurodevelopmental disorder has a germline basis in PPP2R2BDiseaseGenCC HGNC:9305|MONDO:0700092Inferred only
spinocerebellar ataxia type 12 has a germline basis in PPP2R2BDiseaseGenCC HGNC:9305|MONDO:0011439Inferred only

Statements

7 statements

7 statements · 2 reference databases · Subject: PPP2R2B · Sources: Hetionet, WikiPathways

Search this listOrder

PPP2R2B interacts with CHEK2ProteinHetionet hetionet:interacts:11200-5521Inferred only
PPP2R2B interacts with RAC1ProteinHetionet hetionet:interacts:5521-5879Inferred only
PPP2R2B interacts with TP53ProteinHetionet hetionet:interacts:5521-7157Inferred only
PPP2R2B participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
PPP2R2B participates in Glycogen synthesis and degradationPathwayWikiPathways WP500Inferred only
PPP2R2B participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
PPP2R2B participates in Wnt signaling and pluripotencyPathwayWikiPathways WP399Inferred only

Other names

4 names

Resolves to: PPP2R2B

Also called: PP2A subunit B isoform B55-betaPP2A subunit B isoform betaPP2A subunit B isoform PR55-betaPP2A subunit B isoform R2-beta

← Every protein Find it in the graph →