Proteins/UNIPROT:Q15319

POU4F3

ProteinUNIPROT:Q15319

Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity)..

Function from UniProtKB (Q15319), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

autosomal dominant nonsyndromic hearing loss has a germline basis in POU4F3DiseaseGenCC HGNC:9220|MONDO:0019587Inferred only
autosomal dominant nonsyndromic hearing loss 15 has a germline basis in POU4F3DiseaseGenCC HGNC:9220|MONDO:0011226Inferred only
nonsyndromic genetic hearing loss has a germline basis in POU4F3DiseaseGenCC HGNC:9220|MONDO:0019497Inferred only

Statements

12 statements

12 statements · 2 reference databases · Subject: POU4F3 · Sources: gene ontology, Hetionet

Order

GRIN1 covaries with POU4F3ProteinHetionet hetionet:covaries:2902-5459Inferred only
H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 covaries with POU4F3ProteinHetionet hetionet:covaries:5459-8339Inferred only
POU4F3 covaries with IPO13ProteinHetionet hetionet:covaries:5459-9670Inferred only
KLHL29 covaries with POU4F3ProteinHetionet hetionet:covaries:114818-5459Inferred only
LPAR4 covaries with POU4F3ProteinHetionet hetionet:covaries:2846-5459Inferred only
POU4F3 covaries with NKX2-1ProteinHetionet hetionet:covaries:5459-7080Inferred only
POU4F3 covaries with SPRED3ProteinHetionet hetionet:covaries:399473-5459Inferred only
POU4F3 covaries with SSTR1ProteinHetionet hetionet:covaries:5459-6751Inferred only
POU4F3 covaries with TRAPPC5ProteinHetionet hetionet:covaries:126003-5459Inferred only
USP35 covaries with POU4F3ProteinHetionet hetionet:covaries:5459-57558Inferred only
POU4F3 regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q15319|GO:0045944Inferred only
POU4F3 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q15319|GO:0006357Inferred only

Other names

4 names

Resolves to: POU4F3

Also called: Brain-3CBrain-specific homeobox/POU domain protein 3CBrn-3CBRN3C

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