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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q13519

PNOC

Protein·UNIPROT:Q13519

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[Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development..

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[Nocistatin]: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia..

[Orphanin FQ2]: Has potent analgesic activity..

Function from UniProtKB (Q13519), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

14 statements

14 statements · 4 reference databases · Subject: PNOC · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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PNOC covaries with CPNE6ProteinHetionet hetionet:covaries:5368-9362Inferred only
PNOC covaries with SNORCProteinHetionet hetionet:covaries:389084-5368Inferred only
OPRL1 interacts with PNOCProteinHetionet hetionet:interacts:4987-5368Inferred only
PNOC participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
PNOC participates in G alpha (i) signalling eventsPathwayReactome R-HSA-418594Inferred only
PNOC participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
PNOC participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
PNOC participates in Peptide ligand-binding receptorsPathwayReactome R-HSA-375276Inferred only
PNOC participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
PNOC participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
PNOC participates in Vitamin D receptor pathwayPathwayWikiPathways WP2877Inferred only
PNOC regulates regulation of dopamine secretionBiological processgene ontology Q13519|GO:0014059Inferred only

Show the remaining 2

PNOC regulates regulation of synaptic transmission, GABAergicBiological processgene ontology Q13519|GO:0032228Inferred only
PNOC regulates regulation of synaptic transmission, glutamatergicBiological processgene ontology Q13519|GO:0051966Inferred only

Other names

4 names

Resolves to: PNOC

Also called: ; Orphanin FQ2]OFQOrphanin FQPPNOC

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