Proteins/UNIPROT:Q9H2J4

PDCL3

ProteinUNIPROT:Q9H2J4

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis..

Function from UniProtKB (Q9H2J4), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

megacystis-microcolon-intestinal hypoperistalsis syndrome has a germline basis in PDCL3DiseaseGenCC HGNC:28860|MONDO:0025986Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: PDCL3 · Sources: gene ontology, Hetionet

Order

GDF6 covaries with PDCL3ProteinHetionet hetionet:covaries:392255-79031Inferred only
UBC interacts with PDCL3ProteinHetionet hetionet:interacts:7316-79031Inferred only
PDCL3 regulates negative regulation of protein foldingBiological processgene ontology Q9H2J4|GO:1903333Inferred only
PDCL3 regulates negative regulation of ubiquitin-dependent protein catabolic processBiological processgene ontology Q9H2J4|GO:2000059Inferred only
PDCL3 regulates positive regulation of angiogenesisBiological processgene ontology Q9H2J4|GO:0045766Inferred only
PDCL3 regulates positive regulation of endothelial cell proliferationBiological processgene ontology Q9H2J4|GO:0001938Inferred only
PDCL3 regulates positive regulation of gene expressionBiological processgene ontology Q9H2J4|GO:0010628Inferred only
PDCL3 regulates regulation of peptidyl-tyrosine phosphorylationBiological processgene ontology Q9H2J4|GO:0050730Inferred only

Other names

6 names

Resolves to: PDCL3

Also called: HTPHLPPhLP2APhPL3VIAF-1VIAF1Viral IAP-associated factor 1

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