Proteins/UNIPROT:Q13371

PDCL

ProteinUNIPROT:Q13371

Acts as a positive regulator of hedgehog signaling and regulates ciliary function..

[Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.

[Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

Function from UniProtKB (Q13371), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 3 reference databases · Subject: PDCL · Sources: gene ontology, Hetionet, Reactome

Order

PDCL covaries with GPR108ProteinHetionet hetionet:covaries:5082-56927Inferred only
PDCL covaries with PRR7ProteinHetionet hetionet:covaries:5082-80758Inferred only
PDCL covaries with R3HDM4ProteinHetionet hetionet:covaries:5082-91300Inferred only
PDCL covaries with TCFL5ProteinHetionet hetionet:covaries:10732-5082Inferred only
PDCL interacts with CCT5ProteinHetionet hetionet:interacts:22948-5082Inferred only
PDCL interacts with EIF3IProteinHetionet hetionet:interacts:5082-8668Inferred only
GNB1 interacts with PDCLProteinHetionet hetionet:interacts:2782-5082Inferred only
GRK2 interacts with PDCLProteinHetionet hetionet:interacts:156-5082Inferred only
PDCL interacts with IKBKGProteinHetionet hetionet:interacts:5082-8517Inferred only
PDCL interacts with PSMC5ProteinHetionet hetionet:interacts:5082-5705Inferred only
PDCL interacts with TCP1ProteinHetionet hetionet:interacts:5082-6950Inferred only
PDCL interacts with UBCProteinHetionet hetionet:interacts:5082-7316Inferred only

Show the remaining 6

PDCL participates in Chaperonin-mediated protein foldingPathwayReactome R-HSA-390466Inferred only
PDCL participates in Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingPathwayReactome R-HSA-6814122Inferred only
PDCL participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
PDCL participates in Protein foldingPathwayReactome R-HSA-391251Inferred only
PDCL regulates positive regulation of smoothened signaling pathwayBiological processgene ontology Q13371|GO:0045880Inferred only
PDCL regulates regulation of G protein-coupled receptor signaling pathwayBiological processgene ontology Q13371|GO:0008277Inferred only

Other names

4 names

Resolves to: PDCL

Also called: PHLOP1PHLPPhLP1Phosducin-like protein

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