Proteins/UNIPROT:Q8N573

OXR1

ProteinUNIPROT:Q8N573

Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex. Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Involved in protection from oxidative damage. Protects neuronal cells from oxidative stress (By similarity)..

Function from UniProtKB (Q8N573), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

isolated cerebellar hypoplasia/agenesis has a germline basis in OXR1DiseaseGenCC HGNC:15822|MONDO:0008939Inferred only
sensorineural hearing loss disorder has a germline basis in OXR1DiseaseGenCC HGNC:15822|MONDO:0020678Inferred only

Statements

9 statements

9 statements · 1 reference database · Subject: OXR1 · Sources: Hetionet

Order

OXR1 covaries with BRCA1ProteinHetionet hetionet:covaries:55074-672Inferred only
OR13C2 covaries with OXR1ProteinHetionet hetionet:covaries:392376-55074Inferred only
OXR1 covaries with OR4K15ProteinHetionet hetionet:covaries:55074-81127Inferred only
OXR1 covaries with TMSB15AProteinHetionet hetionet:covaries:286527-55074Inferred only
LIG4 interacts with OXR1ProteinHetionet hetionet:interacts:3981-55074Inferred only
NMI interacts with OXR1ProteinHetionet hetionet:interacts:55074-9111Inferred only
OXR1 interacts with VPS35ProteinHetionet hetionet:interacts:55074-55737Inferred only
CFLAR decreases the expression of OXR1ProteinHetionet hetionet:regulates:8837-55074Inferred only
TNFAIP3 increases the expression of OXR1ProteinHetionet hetionet:regulates:7128-55074Inferred only

Other names

1 name

Resolves to: OXR1

Also called: Oxidation resistance protein 1

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