Proteins/UNIPROT:Q8N6M0

OTUD6B

ProteinUNIPROT:Q8N6M0

[Isoform 1]: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1. May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation. May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation. May also play a role in proteasome assembly and function..

[Isoform 2]: Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability..

Function from UniProtKB (Q8N6M0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies has a germline basis in OTUD6BDiseaseGenCC HGNC:24281|MONDO:0044319Inferred only
syndromic intellectual disability has a germline basis in OTUD6BDiseaseGenCC HGNC:24281|MONDO:0000508Inferred only

Statements

9 statements

9 statements · 3 reference databases · Subject: OTUD6B · Sources: gene ontology, Hetionet, WikiPathways

Order

OTUD6B covaries with ASPMProteinHetionet hetionet:covaries:259266-51633Inferred only
OTUD6B covaries with ID4ProteinHetionet hetionet:covaries:3400-51633Inferred only
OTUD6B covaries with LCE2CProteinHetionet hetionet:covaries:353140-51633Inferred only
MAGEE2 covaries with OTUD6BProteinHetionet hetionet:covaries:139599-51633Inferred only
SUMO1 interacts with OTUD6BProteinHetionet hetionet:interacts:51633-7341Inferred only
UBC interacts with OTUD6BProteinHetionet hetionet:interacts:51633-7316Inferred only
OTUD6B participates in Warburg effect modulated by deubiquitinating enzymes and their substratesPathwayWikiPathways WP5216Inferred only
OTUD6B regulates negative regulation of translationBiological processgene ontology Q8N6M0|GO:0017148Inferred only
OTUD6B regulates positive regulation of translationBiological processgene ontology Q8N6M0|GO:0045727Inferred only

Other names

3 names

Resolves to: OTUD6B

Also called: DUBA-5DUBA5OTU domain-containing protein 6B

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