Proteins/UNIPROT:Q99935

OPRPN

ProteinUNIPROT:Q99935

Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection..

Function from UniProtKB (Q99935), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

2 statements

2 statements · 2 reference databases · Subject: OPRPN · Sources: gene ontology, Hetionet

Order

STATH interacts with OPRPNProteinHetionet hetionet:interacts:58503-6779Inferred only
OPRPN regulates regulation of sensory perception of painBiological processgene ontology Q99935|GO:0051930Inferred only

Other names

6 names

Resolves to: OPRPN

Also called: [Cleaved into: Opiorphin]Basic proline-rich lacrimal proteinBPLPPRL1PROL1Proline-rich protein 1

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