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Proteins/UNIPROT:Q96CM4
[Isoform 1]: Thioredoxin-like protein that protects retinal rod and cone photoreceptors against oxidative stress and photo-oxidative damage. Plays a role in the inhibition of TAU phosphorylation and protects TAU against oxidative stress in the retina (By similarity). Acts as a reducing system for MSRA, facilitating the repair of oxidized proteins such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS) in the lens during oxidative stress conditions..
[Isoform 2]: Plays an important role in retinal cone photoreceptor survival. In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity)..
Function from UniProtKB (Q96CM4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 statements
5 statements · 1 reference database · Subject: NXNL1 · Sources: Hetionet
4 names
Resolves to: NXNL1