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Proteins/UNIPROT:O60462

NRP2

Protein·UNIPROT:O60462

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High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.

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(Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells..

Function from UniProtKB (O60462), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

24 statements

24 statements · 4 reference databases · Subject: NRP2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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NRP2 covaries with EXOC3L1ProteinHetionet hetionet:covaries:283849-8828Inferred only
NRP2 covaries with IGDCC4ProteinHetionet hetionet:covaries:57722-8828Inferred only
FLT1 interacts with NRP2ProteinHetionet hetionet:interacts:2321-8828Inferred only
NRP2 interacts with NRP1ProteinHetionet hetionet:interacts:8828-8829Inferred only
PGF interacts with NRP2ProteinHetionet hetionet:interacts:5228-8828Inferred only
SEMA3B interacts with NRP2ProteinHetionet hetionet:interacts:7869-8828Inferred only
NRP2 interacts with SEMA3CProteinHetionet hetionet:interacts:10512-8828Inferred only
SEMA3F interacts with NRP2ProteinHetionet hetionet:interacts:6405-8828Inferred only
NRP2 interacts with SEMA4FProteinHetionet hetionet:interacts:10505-8828Inferred only
VEGFA interacts with NRP2ProteinHetionet hetionet:interacts:7422-8828Inferred only
NRP2 participates in Axon guidancePathwayReactome R-HSA-422475Inferred only
NRP2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only

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NRP2 participates in Epithelial to mesenchymal transition in colorectal cancerPathwayWikiPathways WP4239Inferred only
NRP2 participates in L1CAM interactionsPathwayReactome R-HSA-373760Inferred only
NRP2 participates in Nervous system developmentPathwayReactome R-HSA-9675108Inferred only
NRP2 participates in Neuropilin interactions with VEGF and VEGFRPathwayReactome R-HSA-194306Inferred only
NRP2 participates in NrCAM interactionsPathwayReactome R-HSA-447038Inferred only
NRP2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
NRP2 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
NRP2 participates in Signaling by VEGFPathwayReactome R-HSA-194138Inferred only
NRP2 participates in VEGFA VEGFR2 signalingPathwayWikiPathways WP3888Inferred only
NRP2 regulates positive regulation of endothelial cell migrationBiological processgene ontology O60462|GO:0010595Inferred only
NRP2 regulates positive regulation of endothelial cell proliferationBiological processgene ontology O60462|GO:0001938Inferred only
NRP2 regulates regulation of postsynapse organizationBiological processgene ontology O60462|GO:0099175Inferred only

Other names

3 names

Resolves to: NRP2

Also called: Neuropilin-2Vascular endothelial cell growth factor 165 receptor 2VEGF165R2

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