Proteins/UNIPROT:P54845

NRL

ProteinUNIPROT:P54845

Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner..

Function from UniProtKB (P54845), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

enhanced S-cone syndrome has a germline basis in NRLDiseaseGenCC HGNC:8002|MONDO:0100288Inferred only
retinitis pigmentosa has a germline basis in NRLDiseaseGenCC HGNC:8002|MONDO:0019200Inferred only
retinitis pigmentosa 27 has a germline basis in NRLDiseaseGenCC HGNC:8002|MONDO:0013402Inferred only

Statements

6 statements

6 statements · 2 reference databases · Subject: NRL · Sources: gene ontology, Hetionet

Order

C1QTNF5 covaries with NRLProteinHetionet hetionet:covaries:114902-4901Inferred only
CRX interacts with NRLProteinHetionet hetionet:interacts:1406-4901Inferred only
NRL interacts with EDF1ProteinHetionet hetionet:interacts:4901-8721Inferred only
NRL interacts with FIZ1ProteinHetionet hetionet:interacts:4901-84922Inferred only
NRL regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology P54845|GO:0045944Inferred only
NRL regulates regulation of transcription by RNA polymerase IIBiological processgene ontology P54845|GO:0006357Inferred only

Other names

2 names

Resolves to: NRL

Also called: D14S46ENeural retina-specific leucine zipper protein

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