Proteins/UNIPROT:Q15406

NR6A1

ProteinUNIPROT:Q15406

Orphan nuclear receptor that binds to a response element containing the sequence 5'-TCAAGGTCA-3'. Acts as a regulator of embryonic stem cell pluripotency by mediating repression of POU5F1/OCT4: binds to the DR0 element within the POU5F1/OCT4 promoter and inhibits POU5F1/OCT4 expression during embryonic stem cell differentiation. Involved in the regulation of gene expression in germ cell development during gametogenesis (By similarity)..

Function from UniProtKB (Q15406), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 2 reference databases · Subject: NR6A1 · Sources: gene ontology, Hetionet

Order

NR6A1 covaries with NKX2-5ProteinHetionet hetionet:covaries:1482-2649Inferred only
OR1D5 covaries with NR6A1ProteinHetionet hetionet:covaries:2649-8386Inferred only
OR2M4 covaries with NR6A1ProteinHetionet hetionet:covaries:26245-2649Inferred only
ZFP14 covaries with NR6A1ProteinHetionet hetionet:covaries:2649-57677Inferred only
NR6A1 covaries with ZNF26ProteinHetionet hetionet:covaries:2649-7574Inferred only
NR6A1 covaries with ZNF554ProteinHetionet hetionet:covaries:115196-2649Inferred only
NR6A1 interacts with GNB5ProteinHetionet hetionet:interacts:10681-2649Inferred only
NR6A1 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q15406|GO:0000122Inferred only
NR6A1 regulates positive regulation of mesenchymal stem cell differentiationBiological processgene ontology Q15406|GO:2000741Inferred only
NR6A1 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q15406|GO:0006357Inferred only

Other names

6 names

Resolves to: NR6A1

Also called: GCNFGerm cell nuclear factorhGCNFhRTRRetinoid receptor-related testis-specific receptorRTR

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