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Proteins/UNIPROT:Q8WX94

NLRP7

Protein·UNIPROT:Q8WX94

Open in the graph

Component of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. Cytoplasmic lattices are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development. Inhibits CASP1/caspase-1-dependent IL1B secretion..

Function from UniProtKB (Q8WX94), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

complete hydatidiform mole has a germline basis in NLRP7DiseaseGenCC HGNC:22947|MONDO:0016785Inferred only
hydatidiform mole, recurrent, 1 has a germline basis in NLRP7DiseaseGenCC HGNC:22947|MONDO:0009273Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: NLRP7 · Sources: gene ontology, Hetionet, WikiPathways

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CASP1 interacts with NLRP7ProteinHetionet hetionet:interacts:199713-834Inferred only
FAF1 interacts with NLRP7ProteinHetionet hetionet:interacts:11124-199713Inferred only
IL1B interacts with NLRP7ProteinHetionet hetionet:interacts:199713-3553Inferred only
UBC interacts with NLRP7ProteinHetionet hetionet:interacts:199713-7316Inferred only
NLRP7 participates in HLA C allotypes interactions with KIR on dNK cellsPathwayWikiPathways WP5580Inferred only
NLRP7 participates in Nucleotide binding oligomerization domain NOD pathwayPathwayWikiPathways WP1433Inferred only
NLRP7 regulates negative regulation of cytokine production involved in inflammatory responseBiological processgene ontology Q8WX94|GO:1900016Inferred only
NLRP7 regulates negative regulation of interleukin-1 beta productionBiological processgene ontology Q8WX94|GO:0032691Inferred only
NLRP7 regulates negative regulation of protein processingBiological processgene ontology Q8WX94|GO:0010955Inferred only
NLRP7 regulates positive regulation of embryonic developmentBiological processgene ontology Q8WX94|GO:0040019Inferred only
NLRP7 regulates regulation of inflammatory responseBiological processgene ontology Q8WX94|GO:0050727Inferred only

Other names

5 names

Resolves to: NLRP7

Also called: NALP7NOD12Nucleotide-binding oligomerization domain protein 12PYPAF3PYRIN-containing APAF1-like protein 3

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