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Proteins/UNIPROT:Q8NET5

NFAM1

Protein·UNIPROT:Q8NET5

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May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking..

Function from UniProtKB (Q8NET5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

9 statements

9 statements · 3 reference databases · Subject: NFAM1 · Sources: gene ontology, Hetionet, Reactome

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NFAM1 covaries with PRSS21ProteinHetionet hetionet:covaries:10942-150372Inferred only
SYK interacts with NFAM1ProteinHetionet hetionet:interacts:150372-6850Inferred only
ZAP70 interacts with NFAM1ProteinHetionet hetionet:interacts:150372-7535Inferred only
NFAM1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
NFAM1 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
NFAM1 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
NFAM1 regulates positive regulation of B cell receptor signaling pathwayBiological processgene ontology Q8NET5|GO:0050861Inferred only
NFAM1 regulates positive regulation of cytokine productionBiological processgene ontology Q8NET5|GO:0001819Inferred only
NFAM1 regulates regulation of B cell differentiationBiological processgene ontology Q8NET5|GO:0045577Inferred only

Other names

3 names

Resolves to: NFAM1

Also called: Calcineurin/NFAT-activating ITAM-containing proteinCNAIPNFAT-activating protein with ITAM motif 1

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