NAP1L2

Histone chaperone (By similarity). Plays a role in the epigenetic regulation of gene expression during cellular differentiation, by regulating the acetylation status of histone H3 and therefore chromatin accessibility. Plays a role in the differentiation of neuronal cells (By similarity). Increased activity during aging may suppress osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and promote their senescence; recruits SIRT1 to deacetylate histone H3 'Lys-14' at the promoter of osteogenic genes..

Function from UniProtKB (Q9ULW6), read 2026-09-23. CC BY 4.0.