Proteins/UNIPROT:Q96BF6

NACC2

ProteinUNIPROT:Q96BF6

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53..

Function from UniProtKB (Q96BF6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 2 reference databases · Subject: NACC2 · Sources: gene ontology, Hetionet

Order

NACC2 covaries with BCL7AProteinHetionet hetionet:covaries:138151-605Inferred only
NACC2 covaries with KCNH2ProteinHetionet hetionet:covaries:138151-3757Inferred only
EPS8 interacts with NACC2ProteinHetionet hetionet:interacts:138151-2059Inferred only
UBC interacts with NACC2ProteinHetionet hetionet:interacts:138151-7316Inferred only
NACC2 regulates negative regulation of cell population proliferationBiological processgene ontology Q96BF6|GO:0008285Inferred only
NACC2 regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q96BF6|GO:0045892Inferred only
NACC2 regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q96BF6|GO:0000122Inferred only
NACC2 regulates positive regulation of intrinsic apoptotic signaling pathway in response to DNA damageBiological processgene ontology Q96BF6|GO:1902231Inferred only
NACC2 regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q96BF6|GO:0006357Inferred only
CDKN1A decreases the expression of NACC2ProteinHetionet hetionet:regulates:1026-138151Inferred only
HERPUD1 increases the expression of NACC2ProteinHetionet hetionet:regulates:9709-138151Inferred only
IKBKG decreases the expression of NACC2ProteinHetionet hetionet:regulates:8517-138151Inferred only

Show the remaining 2

ILK decreases the expression of NACC2ProteinHetionet hetionet:regulates:3611-138151Inferred only
KDELR3 increases the expression of NACC2ProteinHetionet hetionet:regulates:11015-138151Inferred only

Other names

6 names

Resolves to: NACC2

Also called: BTB/POZ domain-containing protein 14ABTBD14ANAC-2NAC2RBBRepressor with BTB domain and BEN domain

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