Proteins/UNIPROT:Q96AH0

NABP1

ProteinUNIPROT:Q96AH0

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways..

Function from UniProtKB (Q96AH0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

4 statements

4 statements · 2 reference databases · Subject: NABP1 · Sources: Hetionet, Reactome

Order

UBC interacts with NABP1ProteinHetionet hetionet:interacts:64859-7316Inferred only
NABP1 participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
NABP1 participates in RNA polymerase II transcribes snRNA genesPathwayReactome R-HSA-6807505Inferred only
NABP1 participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only

Other names

9 names

Resolves to: NABP1

Also called: hSSB2Nucleic acid-binding protein 1OBFC2AOligonucleotide/oligosaccharide-binding fold-containing protein 2ASensor of single-strand DNA complex subunit B2Sensor of ssDNA subunit B2Single-stranded DNA-binding protein 2SOSS-B2SSB2

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