Proteins/UNIPROT:Q14896

MYBPC3

ProteinUNIPROT:Q14896

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.

Function from UniProtKB (Q14896), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

familial isolated dilated cardiomyopathy has a germline basis in MYBPC3DiseaseGenCC HGNC:7551|MONDO:0700335Inferred only
hypertrophic cardiomyopathy has a germline basis in MYBPC3DiseaseGenCC HGNC:7551|MONDO:0005045Inferred only
hypertrophic cardiomyopathy 4 has a germline basis in MYBPC3DiseaseGenCC HGNC:7551|MONDO:0007268Inferred only
left ventricular noncompaction 10 has a germline basis in MYBPC3DiseaseGenCC HGNC:7551|MONDO:0014163Inferred only

Statements

17 statements

17 statements · 4 reference databases · Subject: MYBPC3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

MYBPC3 covaries with OR10W1ProteinHetionet hetionet:covaries:4607-81341Inferred only
TEX28; TEX28P1; TEX28P2 covaries with MYBPC3ProteinHetionet hetionet:covaries:1527-4607Inferred only
CAPN1 interacts with MYBPC3ProteinHetionet hetionet:interacts:4607-823Inferred only
MYBPC3 interacts with CUL1ProteinHetionet hetionet:interacts:4607-8454Inferred only
MYBPC3 interacts with FBXO32ProteinHetionet hetionet:interacts:114907-4607Inferred only
MYBPC3 interacts with MYH9ProteinHetionet hetionet:interacts:4607-4627Inferred only
MYBPC3 interacts with NCF1ProteinHetionet hetionet:interacts:4607-653361Inferred only
MYBPC3 interacts with SMURF2ProteinHetionet hetionet:interacts:4607-64750Inferred only
MYBPC3 interacts with TNNI3KProteinHetionet hetionet:interacts:4607-51086Inferred only
MYBPC3 interacts with TRIM63ProteinHetionet hetionet:interacts:4607-84676Inferred only
MYBPC3 interacts with TTNProteinHetionet hetionet:interacts:4607-7273Inferred only
MYBPC3 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only

Show the remaining 5

MYBPC3 participates in Striated Muscle ContractionPathwayReactome R-HSA-390522Inferred only
MYBPC3 participates in Striated muscle contraction pathwayPathwayWikiPathways WP383Inferred only
MYBPC3 regulates regulation of cardiac muscle cell contractionBiological processgene ontology Q14896|GO:0086004Inferred only
MYBPC3 regulates regulation of muscle filament slidingBiological processgene ontology Q14896|GO:0032971Inferred only
MYBPC3 regulates regulation of striated muscle contractionBiological processgene ontology Q14896|GO:0006942Inferred only

Other names

2 names

Resolves to: MYBPC3

Also called: C-protein, cardiac muscle isoformCardiac MyBP-C

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