Proteins/UNIPROT:Q8NHP6

MOSPD2

ProteinUNIPROT:Q8NHP6

Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines..

Function from UniProtKB (Q8NHP6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 3 reference databases · Subject: MOSPD2 · Sources: gene ontology, Hetionet, Reactome

Order

EDA2R covaries with MOSPD2ProteinHetionet hetionet:covaries:158747-60401Inferred only
UBC interacts with MOSPD2ProteinHetionet hetionet:interacts:158747-7316Inferred only
MOSPD2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
MOSPD2 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
MOSPD2 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only
MOSPD2 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
MOSPD2 participates in RHOD GTPase cyclePathwayReactome R-HSA-9013405Inferred only
MOSPD2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
MOSPD2 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
MOSPD2 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
MOSPD2 regulates positive regulation of monocyte chemotaxisBiological processgene ontology Q8NHP6|GO:0090026Inferred only
MOSPD2 regulates positive regulation of neutrophil chemotaxisBiological processgene ontology Q8NHP6|GO:0090023Inferred only

Show the remaining 2

PRDX2 decreases the expression of MOSPD2ProteinHetionet hetionet:regulates:7001-158747Inferred only
SRRM1 increases the expression of MOSPD2ProteinHetionet hetionet:regulates:10250-158747Inferred only

Other names

1 name

Resolves to: MOSPD2

Also called: Motile sperm domain-containing protein 2

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