Proteins/UNIPROT:Q6PF18

MORN3

ProteinUNIPROT:Q6PF18

Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis (By similarity)..

Function from UniProtKB (Q6PF18), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

1 statement

1 statement · 1 reference database · Subject: MORN3 · Sources: gene ontology

Order

MORN3 regulates negative regulation of signal transduction by p53 class mediatorBiological processgene ontology Q6PF18|GO:1901797Inferred only

Other names

1 name

Resolves to: MORN3

Also called: MORN repeat-containing protein 3

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