Proteins/UNIPROT:Q8NEH6

MNS1

ProteinUNIPROT:Q8NEH6

Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly (By similarity). May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules..

Function from UniProtKB (Q8NEH6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

heterotaxy, visceral, 9, autosomal, with male infertility has a germline basis in MNS1DiseaseGenCC HGNC:29636|MONDO:0030070Inferred only

Statements

9 statements

9 statements · 2 reference databases · Subject: MNS1 · Sources: gene ontology, Hetionet

Order

KRTAP21-3 covaries with MNS1ProteinHetionet hetionet:covaries:100288323-55329Inferred only
RWDD2A covaries with MNS1ProteinHetionet hetionet:covaries:112611-55329Inferred only
SLMAP covaries with MNS1ProteinHetionet hetionet:covaries:55329-7871Inferred only
ZNF793 covaries with MNS1ProteinHetionet hetionet:covaries:390927-55329Inferred only
EWSR1 interacts with MNS1ProteinHetionet hetionet:interacts:2130-55329Inferred only
MNS1 regulates positive regulation of cilium assemblyBiological processgene ontology Q8NEH6|GO:0045724Inferred only
FAIM increases the expression of MNS1ProteinHetionet hetionet:regulates:55179-55329Inferred only
IRS1 increases the expression of MNS1ProteinHetionet hetionet:regulates:3667-55329Inferred only
UBE2E3 increases the expression of MNS1ProteinHetionet hetionet:regulates:10477-55329Inferred only

Other names

1 name

Resolves to: MNS1

Also called: Meiosis-specific nuclear structural protein 1

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