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Proteins/UNIPROT:Q6ZRQ5
Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, MMS22L acts by binding ssDNA..
Function from UniProtKB (Q6ZRQ5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 statements
6 statements · 1 reference database · Subject: MMS22L · Sources: Hetionet
4 names
Resolves to: MMS22L