Proteins/UNIPROT:Q5VWP3

MLIP

ProteinUNIPROT:Q5VWP3

Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity). Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (By similarity). Binds chromatin (By similarity). May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (By similarity). May also repress MYOCD transcriptional activity (By similarity)..

Function from UniProtKB (Q5VWP3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 1 has a germline basis in MLIPDiseaseGenCC HGNC:21355|MONDO:0859322Inferred only

Statements

5 statements

5 statements · 2 reference databases · Subject: MLIP · Sources: gene ontology, Hetionet

Order

LMNA interacts with MLIPProteinHetionet hetionet:interacts:4000-90523Inferred only
MLIP regulates negative regulation of cardiac muscle hypertrophyBiological processgene ontology Q5VWP3|GO:0010614Inferred only
MLIP regulates negative regulation of cardiac muscle hypertrophy in response to stressBiological processgene ontology Q5VWP3|GO:1903243Inferred only
MLIP regulates negative regulation of transcription by RNA polymerase IIBiological processgene ontology Q5VWP3|GO:0000122Inferred only
MLIP regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q5VWP3|GO:0045944Inferred only

Other names

4 names

Resolves to: MLIP

Also called: C6orf142Cardiac Isl1-interacting proteinCipMuscular-enriched A-type laminin-interacting protein

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