Proteins/UNIPROT:Q8IYU8

MICU2

ProteinUNIPROT:Q8IYU8

Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel..

Function from UniProtKB (Q8IYU8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: MICU2 · Sources: gene ontology, Hetionet, Reactome

Order

COPS5 interacts with MICU2ProteinHetionet hetionet:interacts:10987-221154Inferred only
UBC interacts with MICU2ProteinHetionet hetionet:interacts:221154-7316Inferred only
MICU2 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
MICU2 participates in Mitochondrial calcium ion transportPathwayReactome R-HSA-8949215Inferred only
MICU2 participates in Mitochondrial protein degradationPathwayReactome R-HSA-9837999Inferred only
MICU2 participates in Processing of SMDT1PathwayReactome R-HSA-8949664Inferred only
MICU2 participates in Transport of small moleculesPathwayReactome R-HSA-382551Inferred only
MICU2 regulates negative regulation of mitochondrial calcium ion concentrationBiological processgene ontology Q8IYU8|GO:0051562Inferred only
MICU2 regulates positive regulation of mitochondrial calcium ion concentrationBiological processgene ontology Q8IYU8|GO:0051561Inferred only
EPHA2 increases the expression of MICU2ProteinHetionet hetionet:regulates:1969-221154Inferred only
FOXP3 increases the expression of MICU2ProteinHetionet hetionet:regulates:50943-221154Inferred only
HEBP1 increases the expression of MICU2ProteinHetionet hetionet:regulates:50865-221154Inferred only

Show the remaining 4

MASTL decreases the expression of MICU2ProteinHetionet hetionet:regulates:84930-221154Inferred only
MEGF9 decreases the expression of MICU2ProteinHetionet hetionet:regulates:1955-221154Inferred only
POP4 decreases the expression of MICU2ProteinHetionet hetionet:regulates:10775-221154Inferred only
VRK2 decreases the expression of MICU2ProteinHetionet hetionet:regulates:7444-221154Inferred only

Other names

3 names

Resolves to: MICU2

Also called: EF-hand domain-containing family member A1EFHA1hMICU3

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