Proteins/UNIPROT:Q14696

MESD

ProteinUNIPROT:Q14696

Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4 (By similarity). May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells (By similarity)..

Function from UniProtKB (Q14696), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

osteogenesis imperfecta type 2 has a germline basis in MESDDiseaseGenCC HGNC:13520|MONDO:0008147Inferred only
osteogenesis imperfecta, type 20 has a germline basis in MESDDiseaseGenCC HGNC:13520|MONDO:0032846Inferred only

Statements

13 statements

13 statements · 2 reference databases · Subject: MESD · Sources: gene ontology, Hetionet

Order

APP interacts with MESDProteinHetionet hetionet:interacts:23184-351Inferred only
ATP6V1E1 interacts with MESDProteinHetionet hetionet:interacts:23184-529Inferred only
MESD interacts with BRD4ProteinHetionet hetionet:interacts:23184-23476Inferred only
KPNB1 interacts with MESDProteinHetionet hetionet:interacts:23184-3837Inferred only
LRP5 interacts with MESDProteinHetionet hetionet:interacts:23184-4041Inferred only
LRP6 interacts with MESDProteinHetionet hetionet:interacts:23184-4040Inferred only
PSMA5 interacts with MESDProteinHetionet hetionet:interacts:23184-5686Inferred only
RFC3 interacts with MESDProteinHetionet hetionet:interacts:23184-5983Inferred only
MESD interacts with SNX5ProteinHetionet hetionet:interacts:23184-27131Inferred only
MESD interacts with SNX7ProteinHetionet hetionet:interacts:23184-51375Inferred only
MESD regulates negative regulation of glycoprotein biosynthetic processBiological processgene ontology Q14696|GO:0010561Inferred only
MESD regulates positive regulation of skeletal muscle acetylcholine-gated channel clusteringBiological processgene ontology Q14696|GO:1904395Inferred only

Show the remaining 1

MESD regulates positive regulation of Wnt signaling pathwayBiological processgene ontology Q14696|GO:0030177Inferred only

Other names

8 names

Resolves to: MESD

Also called: KIAA0081LDLR chaperone MESDMESDC2MESDMMesoderm development candidate 2Mesoderm development LRP chaperone MESDMesoderm development proteinRenal carcinoma antigen NY-REN-61

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