Loading the page.
Proteins/UNIPROT:O00187
Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin..
[Mannan-binding lectin serine protease 2 B chain]: Serine protease component of the lectin complement pathway, which catalyzes cleavage and activation of C2 and C4, the next components of the complement pathway..
Function from UniProtKB (O00187), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
17 statements
17 statements · 2 reference databases · Subject: MASP2 · Sources: Hetionet, WikiPathways
4 names
Resolves to: MASP2