Proteins/UNIPROT:Q8NHW3

MAFA

ProteinUNIPROT:Q8NHW3

Transcription factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence..

Function from UniProtKB (Q8NHW3), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

15 statements

15 statements · 4 reference databases · Subject: MAFA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

MAF interacts with MAFAProteinHetionet hetionet:interacts:389692-4094Inferred only
MAPK1 interacts with MAFAProteinHetionet hetionet:interacts:389692-5594Inferred only
MAPK14 interacts with MAFAProteinHetionet hetionet:interacts:1432-389692Inferred only
NEUROD1 interacts with MAFAProteinHetionet hetionet:interacts:389692-4760Inferred only
PDX1 interacts with MAFAProteinHetionet hetionet:interacts:3651-389692Inferred only
SUMO1 interacts with MAFAProteinHetionet hetionet:interacts:389692-7341Inferred only
MAFA participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
MAFA participates in Regulation of beta-cell developmentPathwayReactome R-HSA-186712Inferred only
MAFA participates in Regulation of gene expression in beta cellsPathwayReactome R-HSA-210745Inferred only
MAFA participates in Roles of ceramides in development of insulin resistancePathwayWikiPathways WP5181Inferred only
MAFA participates in Thyroid hormones production and peripheral downstream signaling effectsPathwayWikiPathways WP4746Inferred only
MAFA participates in Type II diabetes mellitusPathwayWikiPathways WP1584Inferred only

Show the remaining 3

MAFA regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q8NHW3|GO:0045944Inferred only
MAFA regulates regulation of DNA-templated transcriptionBiological processgene ontology Q8NHW3|GO:0006355Inferred only
MAFA regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q8NHW3|GO:0006357Inferred only

Other names

3 names

Resolves to: MAFA

Also called: Pancreatic beta-cell-specific transcriptional activatorRIPE3b1 factorV-maf musculoaponeurotic fibrosarcoma oncogene homolog A

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