Proteins/UNIPROT:Q96JY0

MAEL

ProteinUNIPROT:Q96JY0

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity)..

Function from UniProtKB (Q96JY0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 3 reference databases · Subject: MAEL · Sources: gene ontology, Hetionet, Reactome

Order

KRTAP4-8 covaries with MAELProteinHetionet hetionet:covaries:728224-84944Inferred only
MAEL covaries with RAP1GAPProteinHetionet hetionet:covaries:5909-84944Inferred only
ZYX covaries with MAELProteinHetionet hetionet:covaries:7791-84944Inferred only
MAEL participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
MAEL participates in Gene Silencing by RNAPathwayReactome R-HSA-211000Inferred only
MAEL participates in PIWI-interacting RNA (piRNA) biogenesisPathwayReactome R-HSA-5601884Inferred only
MAEL regulates negative regulation of DNA-templated transcriptionBiological processgene ontology Q96JY0|GO:0045892Inferred only
MAEL regulates regulation of miRNA-mediated gene silencingBiological processgene ontology Q96JY0|GO:0060964Inferred only
MAEL increases the expression of ADAT1ProteinHetionet hetionet:regulates:84944-23536Inferred only
MAEL decreases the expression of AURKBProteinHetionet hetionet:regulates:84944-9212Inferred only
MAEL decreases the expression of CDC45ProteinHetionet hetionet:regulates:84944-8318Inferred only
MAEL increases the expression of KCTD5ProteinHetionet hetionet:regulates:84944-54442Inferred only

Show the remaining 4

MAEL decreases the expression of NIT1ProteinHetionet hetionet:regulates:84944-4817Inferred only
MAEL increases the expression of SOCS2ProteinHetionet hetionet:regulates:84944-8835Inferred only
MAEL increases the expression of SRCProteinHetionet hetionet:regulates:84944-6714Inferred only
MAEL decreases the expression of TCEA2ProteinHetionet hetionet:regulates:84944-6919Inferred only

Other names

2 names

Resolves to: MAEL

Also called: maelstrom homologProtein maelstrom homolog

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