Proteins/UNIPROT:Q9NQ48

LZTFL1

ProteinUNIPROT:Q9NQ48

Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function..

Function from UniProtKB (Q9NQ48), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

Bardet-Biedl syndrome has a germline basis in LZTFL1DiseaseGenCC HGNC:6741|MONDO:0015229Inferred only
Bardet-Biedl syndrome 17 has a germline basis in LZTFL1DiseaseGenCC HGNC:6741|MONDO:0014445Inferred only
LZTFL1-related ciliopathy has a germline basis in LZTFL1DiseaseGenCC HGNC:6741|MONDO:1040046Inferred only

Statements

22 statements

22 statements · 4 reference databases · Subject: LZTFL1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

LZTFL1 covaries with MZF1ProteinHetionet hetionet:covaries:54585-7593Inferred only
BBS9 interacts with LZTFL1ProteinHetionet hetionet:interacts:27241-54585Inferred only
FZD5 interacts with LZTFL1ProteinHetionet hetionet:interacts:54585-7855Inferred only
UBC interacts with LZTFL1ProteinHetionet hetionet:interacts:54585-7316Inferred only
UBXN7 interacts with LZTFL1ProteinHetionet hetionet:interacts:26043-54585Inferred only
LZTFL1 participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
LZTFL1 participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
LZTFL1 participates in BBSome-mediated cargo-targeting to ciliumPathwayReactome R-HSA-5620922Inferred only
LZTFL1 participates in Cargo trafficking to the periciliary membranePathwayReactome R-HSA-5620920Inferred only
LZTFL1 participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
LZTFL1 participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
LZTFL1 participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only

Show the remaining 10

LZTFL1 participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
LZTFL1 participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
LZTFL1 regulates negative regulation of protein localization to ciliary membraneBiological processgene ontology Q9NQ48|GO:1903568Inferred only
LZTFL1 regulates negative regulation of protein localization to ciliumBiological processgene ontology Q9NQ48|GO:1903565Inferred only
FECH increases the expression of LZTFL1ProteinHetionet hetionet:regulates:2235-54585Inferred only
FOXJ1 increases the expression of LZTFL1ProteinHetionet hetionet:regulates:2302-54585Inferred only
HSF1 increases the expression of LZTFL1ProteinHetionet hetionet:regulates:3297-54585Inferred only
MOK increases the expression of LZTFL1ProteinHetionet hetionet:regulates:5891-54585Inferred only
MTF2 decreases the expression of LZTFL1ProteinHetionet hetionet:regulates:22823-54585Inferred only
NUCB2 decreases the expression of LZTFL1ProteinHetionet hetionet:regulates:4925-54585Inferred only

Other names

1 name

Resolves to: LZTFL1

Also called: Leucine zipper transcription factor-like protein 1

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