Proteins/UNIPROT:Q9Y5Y7

LYVE1

ProteinUNIPROT:Q9Y5Y7

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericellular hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium..

Function from UniProtKB (Q9Y5Y7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

7 statements

7 statements · 3 reference databases · Subject: LYVE1 · Sources: gene ontology, Hetionet, Reactome

Order

RAD51D covaries with LYVE1ProteinHetionet hetionet:covaries:10894-5892Inferred only
LYVE1 participates in Glycosaminoglycan metabolismPathwayReactome R-HSA-1630316Inferred only
LYVE1 participates in Hyaluronan degradationPathwayReactome R-HSA-2160916Inferred only
LYVE1 participates in Hyaluronan metabolismPathwayReactome R-HSA-2142845Inferred only
LYVE1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
LYVE1 participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
LYVE1 regulates positive regulation of cellular extravasationBiological processgene ontology Q9Y5Y7|GO:0002693Inferred only

Other names

8 names

Resolves to: LYVE1

Also called: Cell surface retention sequence-binding protein 1CRSBP-1CRSBP1Extracellular link domain-containing protein 1HARHyaluronic acid receptorLYVE-1XLKD1

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