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Proteins/UNIPROT:Q8N6I4
Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes. LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes. LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases..
(Microbial infection) Essential for infection by muliple viruses, including SARS-CoV-2, that utilize activated cathepsins for entry after M6P-dependent lysosomal transport..
Function from UniProtKB (Q8N6I4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
6 statements
6 statements · 2 reference databases · Subject: LYSET · Sources: gene ontology, Hetionet
5 names
Resolves to: LYSET