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Proteins/UNIPROT:Q9NPC1

LTB4R2

Protein·UNIPROT:Q9NPC1

Open in the graph

Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.

Function from UniProtKB (Q9NPC1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

12 statements

12 statements · 4 reference databases · Subject: LTB4R2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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KRTAP19-5 covaries with LTB4R2ProteinHetionet hetionet:covaries:337972-56413Inferred only
LTB4R2 participates in Class A/1 (Rhodopsin-like receptors)PathwayReactome R-HSA-373076Inferred only
LTB4R2 participates in Eicosanoid ligand-binding receptorsPathwayReactome R-HSA-391903Inferred only
LTB4R2 participates in Eicosanoid metabolism via lipooxygenases LOX PathwayWikiPathways WP4721Inferred only
LTB4R2 participates in G alpha (q) signalling eventsPathwayReactome R-HSA-416476Inferred only
LTB4R2 participates in GPCR downstream signallingPathwayReactome R-HSA-388396Inferred only
LTB4R2 participates in GPCR ligand bindingPathwayReactome R-HSA-500792Inferred only
LTB4R2 participates in GPCRs otherPathwayWikiPathways WP117Inferred only
LTB4R2 participates in Leukotriene receptorsPathwayReactome R-HSA-391906Inferred only
LTB4R2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
LTB4R2 participates in Signaling by GPCRPathwayReactome R-HSA-372790Inferred only
LTB4R2 regulates negative regulation of adenylate cyclase activityBiological processgene ontology Q9NPC1|GO:0007194Inferred only

Other names

7 names

Resolves to: LTB4R2

Also called: BLT2RBLTR2Leukotriene B4 receptor BLT2LTB4 receptor JULF2LTB4-R 2LTB4-R2Seven transmembrane receptor BLTR2

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