Proteins/UNIPROT:Q8TE12

LMX1A

ProteinUNIPROT:Q8TE12

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity)..

Function from UniProtKB (Q8TE12), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

autosomal dominant nonsyndromic hearing loss has a germline basis in LMX1ADiseaseGenCC HGNC:6653|MONDO:0019587Inferred only
autosomal dominant nonsyndromic hearing loss 7 has a germline basis in LMX1ADiseaseGenCC HGNC:6653|MONDO:0011074Inferred only

Statements

17 statements

17 statements · 3 reference databases · Subject: LMX1A · Sources: gene ontology, Hetionet, WikiPathways

Order

BHLHE22 covaries with LMX1AProteinHetionet hetionet:covaries:27319-4009Inferred only
ERCC3 covaries with LMX1AProteinHetionet hetionet:covaries:2071-4009Inferred only
FCAR covaries with LMX1AProteinHetionet hetionet:covaries:2204-4009Inferred only
LMX1A covaries with FCRLBProteinHetionet hetionet:covaries:127943-4009Inferred only
JRKL covaries with LMX1AProteinHetionet hetionet:covaries:4009-8690Inferred only
OR8D2 covaries with LMX1AProteinHetionet hetionet:covaries:283160-4009Inferred only
LMX1A covaries with RGS4ProteinHetionet hetionet:covaries:4009-5999Inferred only
RHBDL1 covaries with LMX1AProteinHetionet hetionet:covaries:4009-9028Inferred only
LMX1A covaries with SPATA46ProteinHetionet hetionet:covaries:284680-4009Inferred only
TMEM238 covaries with LMX1AProteinHetionet hetionet:covaries:388564-4009Inferred only
XKR6 covaries with LMX1AProteinHetionet hetionet:covaries:286046-4009Inferred only
ISL1 interacts with LMX1AProteinHetionet hetionet:interacts:3670-4009Inferred only

Show the remaining 5

LMX1A interacts with LHX3ProteinHetionet hetionet:interacts:4009-8022Inferred only
LMX1A interacts with TCF3ProteinHetionet hetionet:interacts:4009-6929Inferred only
LMX1A participates in Dopaminergic neurogenesisPathwayWikiPathways WP2855Inferred only
LMX1A regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q8TE12|GO:0045944Inferred only
LMX1A regulates regulation of transcription by RNA polymerase IIBiological processgene ontology Q8TE12|GO:0006357Inferred only

Other names

3 names

Resolves to: LMX1A

Also called: LIM/homeobox protein 1.1LIM/homeobox protein LMX1ALMX-1.1

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