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Proteins/UNIPROT:Q8TAF8

LHFPL5

Protein·UNIPROT:Q8TAF8

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Auxiliary subunit of the mechanotransducer (MET) non-specific cation channel complex located at the tips of the shorter stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. Functionally couples PCDH15 to the transduction channel..

Function from UniProtKB (Q8TAF8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

3 rows

autosomal recessive nonsyndromic hearing loss 67 has a germline basis in LHFPL5DiseaseGenCC HGNC:21253|MONDO:0012460Inferred only
hearing loss, autosomal recessive has a germline basis in LHFPL5DiseaseGenCC HGNC:21253|MONDO:0019588Inferred only
nonsyndromic genetic hearing loss has a germline basis in LHFPL5DiseaseGenCC HGNC:21253|MONDO:0019497Inferred only

Statements

6 statements

6 statements · 2 reference databases · Subject: LHFPL5 · Sources: Hetionet, Reactome

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ARL4A covaries with LHFPL5ProteinHetionet hetionet:covaries:10124-222662Inferred only
LHFPL5 covaries with PGRMC2ProteinHetionet hetionet:covaries:10424-222662Inferred only
LHFPL5 participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
LHFPL5 participates in Sensory processing of soundPathwayReactome R-HSA-9659379Inferred only
LHFPL5 participates in Sensory processing of sound by inner hair cells of the cochleaPathwayReactome R-HSA-9662360Inferred only
LHFPL5 participates in Sensory processing of sound by outer hair cells of the cochleaPathwayReactome R-HSA-9662361Inferred only

Other names

3 names

Resolves to: LHFPL5

Also called: Lipoma HMGIC fusion partner-like 5 proteinTetraspan membrane protein of hair cell stereociliaTMHS

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