Proteins/UNIPROT:O15243

LEPROT

ProteinUNIPROT:O15243

Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability..

Function from UniProtKB (O15243), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

5 statements

5 statements · 2 reference databases · Subject: LEPROT · Sources: gene ontology, Hetionet

Order

LEPR interacts with LEPROTProteinHetionet hetionet:interacts:3953-54741Inferred only
LEPROT regulates negative regulation of growth hormone receptor signaling pathwayBiological processgene ontology O15243|GO:0060400Inferred only
LEPROT regulates negative regulation of protein localization to cell surfaceBiological processgene ontology O15243|GO:2000009Inferred only
LEPROT regulates negative regulation of receptor signaling pathway via JAK-STATBiological processgene ontology O15243|GO:0046426Inferred only
LEPROT regulates positive regulation of establishment of protein localization to mitochondrionBiological processgene ontology O15243|GO:1903749Inferred only

Other names

6 names

Resolves to: LEPROT

Also called: Endospanin-1LEPRLeptin receptor overlapping transcript proteinOB-R gene-related proteinOB-RGRPOBR

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