Proteins/UNIPROT:P48668

KRT6C

ProteinUNIPROT:P48668

Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with the type I keratins, likely including KRT16 and KRT17, assembling keratin intermediate filament networks that contribute to the structural framework and mechanical resilience of stratified epithelia, particularly in palmoplantar epidermis..

Function from UniProtKB (P48668), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

palmoplantar keratoderma, nonepidermolytic, focal or diffuse has a germline basis in KRT6CDiseaseGenCC HGNC:20406|MONDO:0014327Inferred only

Statements

11 statements

11 statements · 3 reference databases · Subject: KRT6C · Sources: Hetionet, Reactome, WikiPathways

Order

KRT6A covaries with KRT6CProteinHetionet hetionet:covaries:286887-3853Inferred only
OR52W1 covaries with KRT6CProteinHetionet hetionet:covaries:120787-286887Inferred only
COPS5 interacts with KRT6CProteinHetionet hetionet:interacts:10987-286887Inferred only
CUL1 interacts with KRT6CProteinHetionet hetionet:interacts:286887-8454Inferred only
CUL2 interacts with KRT6CProteinHetionet hetionet:interacts:286887-8453Inferred only
IQCB1 interacts with KRT6CProteinHetionet hetionet:interacts:286887-9657Inferred only
UBC interacts with KRT6CProteinHetionet hetionet:interacts:286887-7316Inferred only
KRT6C participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
KRT6C participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
KRT6C participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only
KRT6C participates in Pancreatic cancer subtypesPathwayWikiPathways WP5390Inferred only

Other names

9 names

Resolves to: KRT6C

Also called: CK-6CCK-6ECytokeratin-6CCytokeratin-6EK6CKeratin K6hKeratin-6CKRT6EType-II keratin Kb12

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