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Proteins/UNIPROT:P19013

KRT4

Protein·UNIPROT:P19013

Open in the graph

Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type I keratin KRT13, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium..

Function from UniProtKB (P19013), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

hereditary mucosal leukokeratosis has a germline basis in KRT4DiseaseGenCC HGNC:6441|MONDO:0015748Inferred only
white sponge nevus 1 has a germline basis in KRT4DiseaseGenCC HGNC:6441|MONDO:0008676Inferred only

Statements

8 statements

8 statements · 3 reference databases · Subject: KRT4 · Sources: gene ontology, Hetionet, Reactome

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DAZAP1 covaries with KRT4ProteinHetionet hetionet:covaries:26528-3851Inferred only
LBH covaries with KRT4ProteinHetionet hetionet:covaries:3851-81606Inferred only
KRT4 interacts with CUL3ProteinHetionet hetionet:interacts:3851-8452Inferred only
KRT4 interacts with UBCProteinHetionet hetionet:interacts:3851-7316Inferred only
KRT4 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
KRT4 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
KRT4 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only
KRT4 regulates negative regulation of epithelial cell proliferationBiological processgene ontology P19013|GO:0050680Inferred only

Other names

6 names

Resolves to: KRT4

Also called: CK-4CYK4Cytokeratin-4K4Keratin-4Type-II keratin Kb4

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