Proteins/UNIPROT:P35908

KRT2

ProteinUNIPROT:P35908

Structural component of intermediate filaments in suprabasal keratinocytes of stratified epidermis. Forms heteropolymers with type I keratins (e.g., KRT10), assembling into keratin intermediate filament networks that support mechanical integrity and resilience of the differentiating epidermis. Contributes to terminal differentiation and cornification of keratinocytes and plays a role in establishing the epidermal barrier..

Function from UniProtKB (P35908), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

superficial epidermolytic ichthyosis has a germline basis in KRT2DiseaseGenCC HGNC:6439|MONDO:0007813Inferred only

Statements

23 statements

23 statements · 3 reference databases · Subject: KRT2 · Sources: gene ontology, Hetionet, Reactome

Order

RRP1 covaries with KRT2ProteinHetionet hetionet:covaries:3849-8568Inferred only
KRT2 interacts with CAND1ProteinHetionet hetionet:interacts:3849-55832Inferred only
KRT2 interacts with COPS5ProteinHetionet hetionet:interacts:10987-3849Inferred only
KRT2 interacts with COPS6ProteinHetionet hetionet:interacts:10980-3849Inferred only
KRT2 interacts with CUL1ProteinHetionet hetionet:interacts:3849-8454Inferred only
KRT2 interacts with CUL2ProteinHetionet hetionet:interacts:3849-8453Inferred only
KRT2 interacts with CUL3ProteinHetionet hetionet:interacts:3849-8452Inferred only
KRT2 interacts with CUL4AProteinHetionet hetionet:interacts:3849-8451Inferred only
KRT2 interacts with CUL5ProteinHetionet hetionet:interacts:3849-8065Inferred only
KRT2 interacts with DCUN1D1ProteinHetionet hetionet:interacts:3849-54165Inferred only
KRT2 interacts with EIF4A3ProteinHetionet hetionet:interacts:3849-9775Inferred only
EVPL interacts with KRT2ProteinHetionet hetionet:interacts:2125-3849Inferred only

Show the remaining 11

HDGF interacts with KRT2ProteinHetionet hetionet:interacts:3068-3849Inferred only
KRT2 interacts with IQCB1ProteinHetionet hetionet:interacts:3849-9657Inferred only
KRT2 interacts with MAGOHProteinHetionet hetionet:interacts:3849-4116Inferred only
KRT2 interacts with NEDD8ProteinHetionet hetionet:interacts:3849-4738Inferred only
KRT2 interacts with SMAD3ProteinHetionet hetionet:interacts:3849-4088Inferred only
KRT2 interacts with UBCProteinHetionet hetionet:interacts:3849-7316Inferred only
KRT2 interacts with VCAM1ProteinHetionet hetionet:interacts:3849-7412Inferred only
KRT2 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
KRT2 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
KRT2 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only
KRT2 regulates positive regulation of epidermis developmentBiological processgene ontology P35908|GO:0045684Inferred only

Other names

9 names

Resolves to: KRT2

Also called: CK-2eCytokeratin-2eEpithelial keratin-2eK2eKeratin-2 epidermisKeratin-2eKRT2AKRT2EType-II keratin Kb2

← Every protein Find it in the graph →