Proteins/UNIPROT:Q99456

KRT12

ProteinUNIPROT:Q99456

Structural component of intermediate filaments in the corneal epithelium. Forms heteropolymers with the type II keratin KRT3, assembling into keratin intermediate filament networks that provide mechanical strength and structural integrity to the corneal epithelial layer..

Function from UniProtKB (Q99456), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

corneal dystrophy, Meesmann, 1 has a germline basis in KRT12DiseaseGenCC HGNC:6414|MONDO:0020791Inferred only
Meesmann corneal dystrophy has a germline basis in KRT12DiseaseGenCC HGNC:6414|MONDO:0007379Inferred only

Statements

8 statements

8 statements · 2 reference databases · Subject: KRT12 · Sources: Hetionet, Reactome

Order

FAM171A2 covaries with KRT12ProteinHetionet hetionet:covaries:284069-3859Inferred only
NPB covaries with KRT12ProteinHetionet hetionet:covaries:256933-3859Inferred only
OR8I2 covaries with KRT12ProteinHetionet hetionet:covaries:120586-3859Inferred only
KRT12 interacts with UBCProteinHetionet hetionet:interacts:3859-7316Inferred only
KRT12 interacts with UCHL5ProteinHetionet hetionet:interacts:3859-51377Inferred only
KRT12 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
KRT12 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
KRT12 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only

Other names

4 names

Resolves to: KRT12

Also called: CK-12Cytokeratin-12K12Keratin-12

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