Proteins/UNIPROT:Q8NCW0

KREMEN2

ProteinUNIPROT:Q8NCW0

Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation..

Function from UniProtKB (Q8NCW0), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

10 statements

10 statements · 3 reference databases · Subject: KREMEN2 · Sources: gene ontology, Hetionet, Reactome

Order

UBC interacts with KREMEN2ProteinHetionet hetionet:interacts:7316-79412Inferred only
KREMEN2 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
KREMEN2 participates in Diseases of signal transduction by growth factor receptors and second messengersPathwayReactome R-HSA-5663202Inferred only
KREMEN2 participates in Negative regulation of TCF-dependent signaling by WNT ligand antagonistsPathwayReactome R-HSA-3772470Inferred only
KREMEN2 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
KREMEN2 participates in Signaling by LRP5 mutantsPathwayReactome R-HSA-5339717Inferred only
KREMEN2 participates in Signaling by WNTPathwayReactome R-HSA-195721Inferred only
KREMEN2 participates in Signaling by WNT in cancerPathwayReactome R-HSA-4791275Inferred only
KREMEN2 participates in TCF dependent signaling in response to WNTPathwayReactome R-HSA-201681Inferred only
KREMEN2 regulates negative regulation of ossificationBiological processgene ontology Q8NCW0|GO:0030279Inferred only

Other names

4 names

Resolves to: KREMEN2

Also called: Dickkopf receptor 2Kringle domain-containing transmembrane protein 2Kringle-containing protein marking the eye and the noseKRM2

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