Proteins/UNIPROT:Q12918

KLRB1

ProteinUNIPROT:Q12918

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells..

Function from UniProtKB (Q12918), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

11 statements

11 statements · 3 reference databases · Subject: KLRB1 · Sources: gene ontology, Hetionet, Reactome

Order

KLRB1 covaries with CCDC152ProteinHetionet hetionet:covaries:100129792-3820Inferred only
KLRB1 covaries with FAM47EProteinHetionet hetionet:covaries:100129583-3820Inferred only
KLRB1 covaries with KIF11ProteinHetionet hetionet:covaries:3820-3832Inferred only
KLRB1 covaries with PCDHB4ProteinHetionet hetionet:covaries:3820-56131Inferred only
KLRB1 covaries with ZNF239ProteinHetionet hetionet:covaries:3820-8187Inferred only
KLRB1 interacts with CLEC2DProteinHetionet hetionet:interacts:29121-3820Inferred only
KLRB1 interacts with PTPN6ProteinHetionet hetionet:interacts:3820-5777Inferred only
KLRB1 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
KLRB1 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
KLRB1 participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellPathwayReactome R-HSA-198933Inferred only
KLRB1 regulates regulation of natural killer cell mediated cytotoxicityBiological processgene ontology Q12918|GO:0042269Inferred only

Other names

7 names

Resolves to: KLRB1

Also called: C-type lectin domain family 5 member BCD antigen CD161CLEC5BHNKR-P1aNatural killer cell surface protein P1ANKR-P1ANKRP1A

← Every protein Find it in the graph →