Proteins/UNIPROT:Q8IXQ5

KLHL7

ProteinUNIPROT:Q8IXQ5

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination..

Function from UniProtKB (Q8IXQ5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

4 rows

cold-induced sweating syndrome has a germline basis in KLHL7DiseaseGenCC HGNC:15646|MONDO:0015526Inferred only
PERCHING syndrome has a germline basis in KLHL7DiseaseGenCC HGNC:15646|MONDO:0014890Inferred only
retinitis pigmentosa has a germline basis in KLHL7DiseaseGenCC HGNC:15646|MONDO:0019200Inferred only
retinitis pigmentosa 42 has a germline basis in KLHL7DiseaseGenCC HGNC:15646|MONDO:0013052Inferred only

Statements

5 statements

5 statements · 1 reference database · Subject: KLHL7 · Sources: Hetionet

Order

KLHL7 covaries with MARCKSProteinHetionet hetionet:covaries:4082-55975Inferred only
KLHL7 covaries with TLE2ProteinHetionet hetionet:covaries:55975-7089Inferred only
KLHL7 covaries with TMEM258ProteinHetionet hetionet:covaries:55975-746Inferred only
TRAPPC4 covaries with KLHL7ProteinHetionet hetionet:covaries:51399-55975Inferred only
SRSF3 increases the expression of KLHL7ProteinHetionet hetionet:regulates:6428-55975Inferred only

Other names

1 name

Resolves to: KLHL7

Also called: Kelch-like protein 7

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