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Proteins/UNIPROT:P43630

KIR3DL2

Protein·UNIPROT:P43630

Open in the graph

Receptor on natural killer (NK) cells and T cells for MHC class I molecules. Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions. Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity..

Function from UniProtKB (P43630), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

4 statements

4 statements · 2 reference databases · Subject: KIR3DL2 · Sources: Hetionet, Reactome

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HLA-A interacts with KIR3DL2ProteinHetionet hetionet:interacts:3105-3812Inferred only
KIR3DL2 participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
KIR3DL2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
KIR3DL2 participates in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellPathwayReactome R-HSA-198933Inferred only

Other names

8 names

Resolves to: KIR3DL2

Also called: CD antigen CD158kCD158 antigen-like family member KCD158KNatural killer-associated transcript 4NKAT-4NKAT4p70 natural killer cell receptor clone CL-5p70 NK receptor CL-5

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