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Proteins/UNIPROT:Q14953
Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity. Able to activate NK cells citotoxicity and cytokine production such as IFNG. Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 represented in this entry..
Function from UniProtKB (Q14953), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 statements
4 statements · 2 reference databases · Subject: KIR2DS5 · Sources: Hetionet, Reactome
6 names
Resolves to: KIR2DS5