Proteins/UNIPROT:Q86W47

KCNMB4

ProteinUNIPROT:Q86W47

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations..

Function from UniProtKB (Q86W47), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

24 statements

24 statements · 3 reference databases · Subject: KCNMB4 · Sources: gene ontology, Hetionet, Reactome

Order

KCNMB4 covaries with BTG4ProteinHetionet hetionet:covaries:27345-54766Inferred only
CASP8AP2 covaries with KCNMB4ProteinHetionet hetionet:covaries:27345-9994Inferred only
CEP152 covaries with KCNMB4ProteinHetionet hetionet:covaries:22995-27345Inferred only
CEP55 covaries with KCNMB4ProteinHetionet hetionet:covaries:27345-55165Inferred only
GSAP covaries with KCNMB4ProteinHetionet hetionet:covaries:27345-54103Inferred only
KCNMB4 covaries with HECTD2ProteinHetionet hetionet:covaries:143279-27345Inferred only
IFT27 covaries with KCNMB4ProteinHetionet hetionet:covaries:11020-27345Inferred only
PCNX1 covaries with KCNMB4ProteinHetionet hetionet:covaries:22990-27345Inferred only
KCNMB4 covaries with PDLIM1ProteinHetionet hetionet:covaries:27345-9124Inferred only
PYGO1 covaries with KCNMB4ProteinHetionet hetionet:covaries:26108-27345Inferred only
RRAGD covaries with KCNMB4ProteinHetionet hetionet:covaries:27345-58528Inferred only
SCG5 covaries with KCNMB4ProteinHetionet hetionet:covaries:27345-6447Inferred only

Show the remaining 12

STAG3 covaries with KCNMB4ProteinHetionet hetionet:covaries:10734-27345Inferred only
TEX14 covaries with KCNMB4ProteinHetionet hetionet:covaries:27345-56155Inferred only
KCNMB4 covaries with TTC13ProteinHetionet hetionet:covaries:27345-79573Inferred only
KCNMB4 participates in Ca2+ activated K+ channelsPathwayReactome R-HSA-1296052Inferred only
KCNMB4 participates in cGMP effectsPathwayReactome R-HSA-418457Inferred only
KCNMB4 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
KCNMB4 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
KCNMB4 participates in Nitric oxide stimulates guanylate cyclasePathwayReactome R-HSA-392154Inferred only
KCNMB4 participates in Platelet homeostasisPathwayReactome R-HSA-418346Inferred only
KCNMB4 participates in Potassium ChannelsPathwayReactome R-HSA-1296071Inferred only
KCNMB4 regulates regulation of neurotransmitter secretionBiological processgene ontology Q86W47|GO:0046928Inferred only
KCNMB4 regulates regulation of vasoconstrictionBiological processgene ontology Q86W47|GO:0019229Inferred only

Other names

8 names

Resolves to: KCNMB4

Also called: BK channel subunit beta-4BKbeta4Calcium-activated potassium channel, subfamily M subunit beta-4Charybdotoxin receptor subunit beta-4Hbeta4K(VCA)beta-4Maxi K channel subunit beta-4Slo-beta-4

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