Proteins/UNIPROT:O43448

KCNAB3

ProteinUNIPROT:O43448

Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunit. The beta-3/KCNAB3 subunit may mediate closure of potassium channels (By similarity). Increases inactivation of Kv1.5/KCNA5 alpha subunit-containing channels. May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity (By similarity). The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity (By similarity)..

Function from UniProtKB (O43448), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 4 reference databases · Subject: KCNAB3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ULBP3 covaries with KCNAB3ProteinHetionet hetionet:covaries:79465-9196Inferred only
APP interacts with KCNAB3ProteinHetionet hetionet:interacts:351-9196Inferred only
KCNAB3 interacts with NEDD4LProteinHetionet hetionet:interacts:23327-9196Inferred only
UBC interacts with KCNAB3ProteinHetionet hetionet:interacts:7316-9196Inferred only
KCNAB3 participates in Metapathway biotransformation Phase I and IIPathwayWikiPathways WP702Inferred only
KCNAB3 participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
KCNAB3 participates in Potassium ChannelsPathwayReactome R-HSA-1296071Inferred only
KCNAB3 participates in Voltage gated Potassium channelsPathwayReactome R-HSA-1296072Inferred only
KCNAB3 regulates regulation of potassium ion transmembrane transportBiological processgene ontology O43448|GO:1901379Inferred only

Other names

3 names

Resolves to: KCNAB3

Also called: K(+) channel subunit beta-3KCNA3BKv-beta-3

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